Living with
Parkinson's

Understanding the body’s second brain
Overview

Parkinson's Disease

Constipation is one of the most common non-motor symptoms of Parkinson’s disease (PD), and often times maintaining an active and positive lifestyle can be challenging. Inactivity, poor muscle coordination and posture associated with the disease weaken the muscles of the bowels and pelvic floor, affecting their ability to contract. This circle of dis-ease inevitable affects a person’s ability to manage their condition.
As much as 80% of people diagnosed with PD experience severe constipation*, associated with medications used to treat the disease. Multiple studies have shown that the frequency and severity of constipation increased as Parkinson’s disease progressed**.

* Verbaan, D. et al. Patient-reported autonomic symptoms in Parkinson disease. Neurology 69, 333–341, https://doi.org/10.1212/01.wnl.0000266593.50534.e8 (2007).
** Scientific Reports, published January 12, 2018
Additional good resource: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766597/

THE GUT-BRAIN AXIS

Constipation is not just about the gut…

The Gut-Brain Connection is a scientifically established way of understanding bowel function.

Stress for example, can slow the bowel, lead to constipation and increased intestinal permeability6

Additionally, when the Biological Clock rhythm is not synchronized, constipation can happen.
VIBRANT AND PARKINSON

VIBRANT AND PARKINSON

Vibrant innovative system synchronizes the biological clock, helping the patient’s body do what it already knows, with a non-drug approach to treat constipation symptoms naturally and effectively.

Vibrant offers Parkinson patients, in a clinical trial phase, the opportunity to relieve constipation symptoms , using a non-drug system, without the risk of contraindications.

The system makes bowel movements more predictable, helping regain the quality of life.

Clinical Data

Vibrant is currently conducting a phase II, double-blinded, randomized clinical trial to assess the safety and efficacy of its constipation treatment in relieving symptoms and increasing bowel movement for patients with Parkinson’s disease.

Two additional endpoints are also being evaluated in this trial: absorption efficiency of Levodopa Pharmacokinetics when used in conjunction with the vibrating capsule and the potential impact of the capsule’s stimulation on microbiome composition in the gut.

* Verbaan, D. et al. Patient-reported autonomic symptoms in Parkinson disease. Neurology 69, 333–341, https://doi.org/10.1212/01.wnl.0000266593.50534.e8 (2007).
** Scientific Reports, published January 12, 2018 *** https://www.healthline.com/health/parkinsons/parkinsons-constipation Additional good resource: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766597/