Constipation is one of the most common non-motor symptoms of Parkinson’s disease (PD), and often times maintaining an active and positive lifestyle can be challenging. Inactivity, poor muscle coordination and posture associated with the disease weaken the muscles of the bowels and pelvic floor, affecting their ability to contract. This circle of dis-ease inevitable affects a person’s ability to manage their condition.
As much as 80% of people diagnosed with PD experience severe constipation*, associated with medications used to treat the disease. Multiple studies have shown that the frequency and severity of constipation increased as Parkinson’s disease progressed**.
** Scientific Reports, published January 12, 2018
Additional good resource: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766597/
THE GUT-BRAIN AXIS
The Gut-Brain Connection is a scientifically established way of understanding bowel function.
Stress for example, can slow the bowel, lead to constipation and increased intestinal permeability6
Additionally, when the Biological Clock rhythm is not synchronized, constipation can happen.
VIBRANT AND PARKINSON
VIBRANT AND PARKINSON
Vibrant offers Parkinson patients, in a clinical trial phase, the opportunity to relieve constipation symptoms , using a non-drug system, without the risk of contraindications.
The system makes bowel movements more predictable, helping regain the quality of life.
Vibrant is currently conducting a phase II, double-blinded, randomized clinical trial to assess the safety and efficacy of its constipation treatment in relieving symptoms and increasing bowel movement for patients with Parkinson’s disease.
Two additional endpoints are also being evaluated in this trial: absorption efficiency of Levodopa Pharmacokinetics when used in conjunction with the vibrating capsule and the potential impact of the capsule’s stimulation on microbiome composition in the gut.
** Scientific Reports, published January 12, 2018 *** https://www.healthline.com/health/parkinsons/parkinsons-constipation Additional good resource: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766597/