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Vibrant Delivers Durable Efficacy with Exceptionally Low Diarrhea Rates in Adults with Constipation*
• Sustained improvement in bowel habits and stool form at 3 and 6 months
• Diarrhea in only 0.64% of patients, far below rates reported with commonly used pharmacologic options
New real-world evidence on the Vibrant System™ has been published in Clinical and Translational Gastroenterology, presenting outcomes from 1,722 adults treated across U.S. community practices.
Among patients who completed 3 or 6 months of therapy and used the electronic stool diary, treatment with Vibrant demonstrated consistent, clinically meaningful improvements:
• More than one additional complete spontaneous bowel movement per week on average (p<0.0001)
• Stool form improved from a mean of 2.9 at baseline to 4.1 during treatment
• Straining decreased by 45%, and average toileting time was cut by more than half (from ~33 minutes to ~15 minutes)
These improvements were sustained at both 3- and 6-month follow-up.
Tolerability is where Vibrant clearly stands out. Diarrhea rates in this real-world cohort were markedly lower than those reported with commonly used pharmacologic options for chronic idiopathic constipation (CIC):
| Therapy | Mechanism | Reported diarrhea rate |
|---|---|---|
| Vibrant System™ (real-world) | Non-drug, mechanized colonic stimulation | 0.64% |
| Linaclotide | GC-C agonist | ≈ 15–20% in CIC trials |
| Plecanatide | GC-C agonist | ≈ 5–6% in CIC trials |
| Lubiprostone | Chloride channel (ClC-2) activator | ≈ 10–15% in CIC trials |
Approximate rates shown for adults with chronic idiopathic constipation (CIC) based on published clinical trial data for pharmacologic agents and real-world observational data for Vibrant.
In the Vibrant real-world cohort, diarrhea occurred in only 0.64% of patients, with abdominal pain and bloating/distention each ≤~2%. For patients who have cycled through secretagogues or GC-C agonists due to tolerability concerns, these data highlight Vibrant as an effective, well-tolerated, drug-free option to consider earlier in the treatment journey.
Prescribing the Vibrant System®
A first-in-class, FDA-cleared vibrating capsule for chronic idiopathic constipation in adults — drug-free, with no systemic side effects. Prescribing takes two simple steps.
The Vibrant System® is now dispensed by MedOptions Rx — same treatment, same care.
How to Prescribe
Select Vibrant in your EHR
Please include the patient's ICD-10 diagnosis code(s) — e.g., K59.04 — in the prescription notes, along with any previous use of prescribed constipation medications.
Select MedOptions Rx, Specialty Pharmacy
All prescriptions should be sent to MedOptions Rx, our specialty pharmacy partner. Process through your EHR by choosing MedOptions Rx.
- Phone866-359-7532
- Fax844-956-5987
- NPI1699667147
- Address450 E Devon Ave, Ste 170, Itasca, IL 60143
Calling 866-359-7532? The VibrantConnect Team is option 1 (clinical, product & technical support); MedOptions Rx is option 2 (prescriptions & refills).
Dosing, Ordering & Support
The essentials are shown below — expand any section for the full detail.
Dosing & Administration
One capsule, by mouth, at bedtime — 5 nights a week.
Take one capsule by mouth at bedtime, 5 nights per week. No bowel prep, fasting, or timing with meals is required.
20 capsules = a one-month supply. Refills as clinically appropriate.
Full Instructions for Use
Product Identifiers & Order Tables
Starter Kit 60009-0189-82 · Refill 60009-0189-80 · SIG & GTIN inside.
| Product | NDC | GTIN-14 | Dispense |
|---|---|---|---|
| Vibrant Starter Kit (new patients) | 60009-0189-82 | 860009189829 | 1 kit / 30 days |
| Vibrant Capsules (refill) | 60009-0189-80 | 860009189805 | 20 caps / 30 days |
SIG: Take once daily, up to 5×/week, at bedtime. Notes: include ICD-10 for CIC (e.g., K59.04) and prior treatment history.
Ordering for the VA
Referral → secure e-fax to MedOptions Rx → PO & refills for Veterans.
- Submit forms. For new patients, enter a Prosthetics consult for the Vibrant Starter Kit; complete the VA Referral Form and send it to your VA Pharmacy.
- Pharmacy review & e-fax. VA Pharmacy reviews and e-faxes MedOptions Rx at 844-956-5987.
- Payment. Issue PO to Vibrant Gastro, Inc.; MedOptions Rx e-invoices via Tungsten on Vibrant's behalf. Credit card available on request.
- Refills. The pharmacy contacts the VA 3–4 business days before the next refill to confirm dispensing and payment.
- Fulfillment. Typical shipment 2–5 business days to the Veteran's home or VA Pharmacy.
FSS Contract # 36F79725D0174 | UEI GDBXXGNGXH75 | CAGE 9TXD2
Who to Contact
Call 866-359-7532 — press 1 for VibrantConnect, press 2 for MedOptions Rx.
VibrantConnect Team
Medical, clinical, product & technical support.
Phone: 866-359-7532
Email: service@vibrantgastro.com
Web: vibrantgastro.com
MedOptions Rx
Prescriptions, transfers & refills.
Phone: 866-359-7532
Fax: 844-956-5987
NPI: 1699667147
450 E Devon Ave, Ste 170, Itasca, IL 60143
Intended for U.S. healthcare professionals. The Vibrant System® is FDA-cleared for the treatment of chronic idiopathic constipation in adults. Please refer to the full Instructions for Use before prescribing. MedOptions Rx is an independent, licensed specialty pharmacy provider; prescription transfers are handled securely under HIPAA. ©2026 Vibrant Gastro, Inc.
Request a 1-on-1 Clinician Walkthrough
Learn how Vibrant® delivers drug-free, FDA-cleared relief for CIC with a 15-minute walkthrough. We’ll cover how it works, prescribing details, and answer any questions you have.
Prefer to talk now? Call 866-359-7532 (press 1 for VibrantConnect) or email service@vibrantgastro.com.
