Vibrant is a first-in-class, non-pharmacological, intraluminal therapy that is proven to be efficacious and safe in patients with chronic idiopathic constipation (CIC). It is indicated for the treatment of adults with chronic idiopathic constipation who have not experienced relief of their bowel symptoms by using laxative therapies at the recommended dosage for at least 1 month.

Randomized, double-blind, multi-center, placebo-controlled phase 3 clinical trial with 312 adult patients diagnosed with chronic idiopathic constipation. The primary endpoints were an increase of 1 or more complete spontaneous bowel movements per week (CSBM responder) or 2 or more CSBMs per week from baseline during at least 6 of the 8 weeks.
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Vibrant should not be used if your patient:
• Has a history of Zenker's diverticulum, dysphagia, esophageal stricture, eosinophilic esophagitis, or achalasia.
• Has a history of significant gastrointestinal disorder including any form of inflammatory bowel disease or gastrointestinal malignancy (celiac disease excepted if treated & in remission) &/or anal fissures/fistulas.
• Has a history of complicated/obstructive diverticular disease.
• Has a history of intestinal or colonic obstruction, or suspected obstruction.
• Currently has clinical evidence of significant gastroparesis.
• Is pregnant or lactating.